Friday, 2 December 2011

ANALYST GRADE III

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DRUGS CONTROL
(CATEGORY NO. 180/2010)
Date & Time: 23/12/2011 Friday 08.00 AM  to 09.15 AM

Number of Candidates : SC - 127


1.   Pharmaceutical Chemistry
Sources of impurities in pharmaceutical substances.  Gastrointestinal
agents and related compounds, Topical agents, Dental products,
Electrolytes used for replacement therapy, Gases, Essential and Trace
ions,  pharmaceutical Aids,  Sclerosing agents,  Expectorants, Sedatives,
Antidotes and Respiratory stimulants.
Study of classification,  mechanism of action and uses of selected
drugs – General anaesthetics, Local anaesthetics,  sedatives and
Hypnotics, Antipsychotics, Anticonvulsants,  Antidepressants, adrenergic
antagonists, cholinergic drugs, cholinergic blocking agents, Antipyretics,
Narcotic analgesics, Non steroidal anti inflammatory agents,
Antihistaminic agents,  H2 receptor antagonist and protein pump
inhibitors, Diuretics, Antihypertensive agents, Oral hypoglycemic agents
and anti-thyroid agents, Local anti infective agents, Anti fungal agents,
Anti-tubercular agents,Anti-protozoal agents, Anthelmintics, Antimalarials, Sulfonamides and Sulfones, Antibiotics, Antiviral agents and
Anti-neoplastic agents.
2.   Pharmaceutical  Analysis
Different techniques of analysis.  Neutralization titrations,  Non
aqueous titrations, precipitation titrations, Complexometric titrations,
Oxidation – reduction titrations,Gravimetric analysis, Diazotisations
titrations, Kjeldhal method of nitrogen estimation, Gasometry, Karl Fischer
method.   Chromatography, Ion Exchangers, Potentiometric titrations,
Conductometric titrations, Thermal Analysis,  Polarography, Amperometry,
Electrophoresis,  Turbidimetry and Nephelometry,   UV and visible
Spectrophotometry,  Fluorimetry,  Nuclear Magnetic ResonanceSpectroscopy, Mass Spectrometry,  Flame Photometre,
EmissionSpectroscopy, Atomic Absorption Spectroscopy, X-Ray diffraction
& Radio Immuno Assay,   Quality Assurance.
3.   Pharmaceutics
Pharmaceutical Calculations,  Posology.  Powders, Solutions,  Aromatic
Waters,  Mixtures,  Emulsions,  Lotions, Liniments,  Paints,  Lozenges,
Jellies,  Pastes,  Suppositories,  Extraction.  Physical, Chemical,
Therapeutic  incompatibilities.
Heat Transfer,  Mechanical separation,  Filtration and Centrifugation,
Size Reduction and Size separation,  Evaporation,  Distillation, Dying and
Mixing.
Diffusion and Dissolution,  Liquid interfaces,  surface active agents,
Disperse System, Colloids,  Viscosity and Rheology,  Kinetic and Drug
Stability,  Micro meritics and Power Rheology,  Complexations methods for
enhancement of stability,  Radio Pharmaceuticals.
Bio-Pharmaceutics,  Absorption,  Distribution, Metabolism and
Elimination.  Compartment models.  Pharmaceutical Tablets,  Capsules,
Sterile products, Pharmaceutical Aerosols,  Surgical ligatures and Sutures,
Blood products and Plasma substitutes,  Stability problems and
stabilization techniques of Pharmaceutical dosage forms.  Cosmetics,
Controlled drug delivery systems,  Microencapsulation and transdermal
drug delivery systems.
4.   Pharmacology
Definitions of Drugs,  proprietary name, non-proprietary name,
Pharmaco-therapeutics, Pharmaco-kinetics, Pharmaco-dynamics,
toxicology, Bioequivalence, Chemotherapy, drug interaction, adverse drug
reactions & Pharmaco-vigilance, Pharmaco-economics, Pharmacoepidemiology, orphan drugs.
Routes of drug administration and factors governing choice of routes
Pharmaco-kinetics – Absorption, distribution, Bio-transformation,
Excretion
Pharmaco-dynamics – Drug Dose & Dosage, Rational use of
medications
Pharmaco-genetic variation in drug action, Principles of  Toxicology
Drug interactions – Adverse effect of Drugs, Pharmacology of Drugs in
special groups – pregnancy, lactation  peadiatrics  and the elderly, Chrono
Pharmacology
Pharmacology of the following classes of Drugs
Drugs acting on autonomic nervous system, Autocoids and their
antagonists, Cardio Vascular drugs,  Drugs acting on respiratory tract,
Drugs acting on endocrine system
Bio assay of insulin, digitalis, adrenaline, acetyl-choline, histamine,
Oxytocin, d-tubocurarine,  Antihaemophilic fraction,  Heparin Sodium,
Diphtheria antitoxin, Anti rabies vaccine.
Drug discovery and new drug development
Bio-informatics
Pharmacology  of the following groups of drugs – Drugs acting on
central nervous system, Local anaesthetics,  Drugs acting on uterus,
Drugs affecting renal function:  Diuretics & antidiuretics,  Drugs acting on
the blood & blood forming organs,  Pharmacology of vitamins , Heavy
metals & Heavy metal antagonists,  Enzyme in therapy,  Therapeutic
gases,  Drugs acting on skin.
Anti-microbial Drugs & Chemotherapy, Immuno-Pharmacology,  Gene
therapy.
5.   Pharmacognosy
Study of the following families with special reference to medicinally
important plants, Apocynaceae,  Solanaceae, Umbelliferae, Leguminosae,
Rubiaceae and Labiatae.
Systematic Phamacognostic study of following – Carbohydrates and
derived products –Lipids
Study of drugs containing resins and resin combinations
Study of tanninsand tannin containing drugs
Volatile Oils , study of fibres used in Pharmacy.  Study of
pharmaceutical aids.  Drugs of animal origin.
Chemistry, biogenesis and pharmacological  activity of  medicinally
important  monoterpenes,  sesquiterpenes, Diterpenes and Triterpenoids
Glycosides : Chemistry and  biosynthesis
Alkaloids: Chemistry, Biogenesis and Pharmacological activity
Chemistry and Biognesis of medicinally important ligans, Quassinoids
and Flavonoids
Plant tissue culture, Totipotency, types of cultures, nutritional
requirements, growth and  their maintenance,  Application of plant tissue
culture in pharmacognosy.
Gene Transfer, Gene mapping of plants, transgenic plants, introduction
to DNA finger printing
Herbal Drug Technology – Development and Evaluation of herbal
formulations.
Adulteration and Evaluation of crude drug.  Standards for herbal
formulation.  Herbaceous health foods.  Herbal cosmetics.  Study of
biological sources,  cultivation, commercial varieties, chemical
constituents, substitutes, adulterants, uses, diagnostics, macroscopic and
microscopic features and specific chemical tests of the following groups of
drugs containing – glycosides:   Saponins:  Cardio active sterols :
Anthroquinone cathartics:
Studies of traditional drugs, common vernacular names,  botanical
sources, morphology,  chemical nature of chief constituents,
pharmacology, categories and common uses and marketed formulations
of indigenous drugs – Amla, Kantakari, Satavari, Tylophora, Bhilwa, Arjuna,
Kalijiri, Rasna, Unarnava, Chirata, Apmarg, Gokhru, Shankapushpi,
Brahmi, Methi, Lahsun, Palash, Guggal, Gymnema, Shilajit  and Neem.
Introduction to ayurvedic preparations like Asavas, Gutikas, Tailas,
Choornas, lehyas and Bhasmas.
Systematic study of source, cultivation, collection, processing,
chemical constituents, adulterants, uses, diagnostics, macroscopic and
microscopic features and specific chemical tests of the following alkaloids
containing drugs:  Pyridine & Piperidine, Tropane, Quinoline &  Isoquinoline,  Indole, Imidazole, steroidal, Alkaloidal amines, Glycoalkaloid,
Purines.
Introduction, classification and study of different chromatographic
methods and their  application in evaluation of herbal drugs.
Preparation of the extracts and various   extraction techniques
including super critical fluid  extraction.  Chemotaxonomy of medicinal
plants.   Marine Pharmacognosy, novel medicinal agents from arine
sources.   Classification and preparation of allergenic extracts.
Biological sources, preparation, identification tests and uses of
following enzymes:  Diastase, Bromalein,  Papain, Maltase.   Protein
containing drugs:  Gelatin Collagen, Spirulina
6.   Pharmacy  Practice
Basic Principle of Cell injury & Adaptation.  Inflammation & Repair.
Etiology, Pathophysiology & Clinical Significance of Common diseases.
Neoplasms: brief account on the etiology & pathogenesis of Cancer.
Concept of Health & Disease.   Nutrition:  Classification of food
requirements, Balanced diet,  Nutritional Deficiency Disorders, their
treatment and prevention.
Environment & Health:  Sources of Water Supply,  specifications for
drinking water, purification of water,  water pollution,  health & air,  noise,
light
National Immunization schedule,  principles of disease control &
prevention, hospital acquired infection, prevention & control.
Demography & Family Planning
Communicable Diseases:   Causative agents, Modes of Transmission,
Symptoms and prevention, chicken Pox, Measles, Influenza, Diphtheria,
Whooping Cough, Tuberculosis, Poliomyelitis, Hepatitis,  Cholera, Typhoid,
Food Poisoning,  Helminthiasis, Malaria,  Filariasis,  Rabies,  Trachoma,
Tetanus,  Leprosy,  Syphilis,  Gonorrhea & AIDS
Non-Communicable Diseases:- Etiology, preventive measures & control
– Cancer, Diabetes Mellitus,  Blindness,  Cardio-vascular diseases.
First Aid :  Emergency treatment of shock, Snake bite, Burns & Heart
diseases.
Hospital Pharmacy :  Definition, Classification,  Objectives,  Functions,
Organisation of Hospital  Pharmacy.
Pharmacy & Therapeutic Committee :  Hospital Formulary.  Drug Store
Management & Inventory control.  Drug Distribution System in Hospitals.
Central Sterile Supply Unit & their management.
Professional activities of Clinical Pharmacist.  Interpretation of clinical
Laboratory tests and its significance.  Drugs & Poison Information Service.
Clinical Pharmacokinetics & individualization of drug therapy.   Adverse
drug reactions.  Definition & implication of evidence based medicine.
Pharmacoepidemology.
Clinical Management of the following organ disorders – Cardio-vascular
disorders, Central Nervous Disorders,  Respiratory disorders, Gastro
intestinal disorders, Endocrine disorders,  Infectious disorders,
Hemopoietic disorders.
7.   Pharmaceutical  Jurisprudence
Pharmacy Act 1948,  Drugs & Cosmetics Act 1940,  Medicinal Toilet
Preparations (Excise Duties) Act and Rules,  Narcotic Drugs & Psychotropic
Substances Act,  Drugs & Magic Remedies (Objectionable Advertisements)
Act
Drug Prices Control Order,  AICTE Act,  Patents Act,  Trade &
Merchandise Marks Act, States Shops & Establishments Act,  Minimum
Wages  Act,  Factories Act,  Prevention of Food Adulteration Act & Rules,
Prevention of, Cruelty to Animals Act, Medical Termination of Pregnancy
Act,  The Poisons Act.
8.   Microbiology
Classification of microbes and bacterial taxonomy.  Structure of
bacterial cell.  Identification methods of microbes, stains and types of
staining techniques.
Bacterial nutrition,  cultivation of bacteria,  culture media,  its
classification,  Aerobic and Anaerobic culture methods.  Isolation of pure
culture.  Classification and structure of viruses.  Cultivation of viruses,
Viral replication.  Bacteriophages,  Phage typing.  Introduction to fungi of
medical and pharmaceutical importance.  Fungal reproduction and
cultivation.  Microbial genetic and variation.  Gene cloning and their
applications.  Immunity.  Immunological preparations.  Active & Passive
immunization, Vaccines and Sera,  Their preparations, standardization &
storage.  Antigen – Antibody reactions & their applications.  Control of
Microbes by Physical & Chemical methods.  Antibiotics, Microbial assay of
Antibiotics,  Fermentation process,  Enzyme Immobilization,  Microbial
Transformation.
NOTE: - It may be noted that apart from the topics
detailed above, questions from other topics
prescribed for the educational qualification of the
post may also appear in the question paper. There is
no undertaking that all the topics above may be
covered in the question paper.




Candidates can download the Admission Tickets through 
the Website  www.keralapsc.org 

from 02/12/2011


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